|
|
glycocholate + H2O <=> cholic_acid + glycine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
BMK
|
|
BRENDA:
BR22684
KEGG:
R05835
MetaCyc:
CHOLOYLGLYCINE-HYDROLASE-RXN
SABIO-RK:
5426
|
|
|
|
cholic_acid + NAD+ <=> H+ + NADH + 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic_acid
|
1.1.1.159
7alpha-hydroxysteroid dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
M
|
|
BRENDA:
BR29224
KEGG:
R02792
MetaCyc:
7-ALPHA-HYDROXYSTEROID-DEH-RXN
SABIO-RK:
2666
|
|
|
|
cholic_acid + NADP+ <=> H+ + NADPH + 12-ketochenodeoxycholic_acid
|
1.1.1.176
12alpha-hydroxysteroid dehydrogenase
|
–
|
M
|
|
BRENDA:
BR33657
KEGG:
R02793
MetaCyc:
1.1.1.176-RXN
SABIO-RK:
2667
|
|
|
|
choloyl-CoA + H2O <=> H+ + cholic_acid + CoA
|
2.8.3.25
bile acid CoA-transferase
3.1.2.2
palmitoyl-CoA hydrolase
3.1.2.20
acyl-CoA hydrolase
3.1.2.27
choloyl-CoA hydrolase
|
–
–
–
–
|
K
|
|
BRENDA:
BR48553
KEGG:
R07296
MetaCyc:
3.1.2.27-RXN
SABIO-RK:
8638
|
|
|
|
lithocholoyl-CoA + cholic_acid <=> choloyl-CoA + lithocholic_acid
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
|
BRENDA:
BR51766
KEGG:
R11539
MetaCyc:
RXN-17406
|
|
|
|
deoxycholoyl-CoA + cholic_acid <=> choloyl-CoA + deoxycholate
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
|
BRENDA:
BR51767
KEGG:
R07295
MetaCyc:
RXN-15366
|
|
|
|
ATP + cholic_acid + CoA <=> AMP + diphosphate + choloyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
MK
|
|
BRENDA:
BR90
KEGG:
R02794
MetaCyc:
CHOLATE--COA-LIGASE-RXN
|
|
|
|
taurocholate + H2O <=> cholic_acid + taurine
|
3.5.1.24
choloylglycine hydrolase
3.5.1.74
chenodeoxycholoyltaurine hydrolase
|
–
–
|
MK
|
|
BRENDA:
BS140404
KEGG:
R02797
MetaCyc:
RXN-17385
SABIO-RK:
2669
|
|
|
|
cholic_acid + NAD+ <=> 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic_acid + NADH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.395
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
–
|
M
|
|
BRENDA:
BS188316;
BS230636-a
MetaCyc:
RXN-11471
SABIO-RK:
15076
|
|
|
|
cholic_acid + NADP+ <=> 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic_acid + NADPH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.392
3alpha-hydroxycholanate dehydrogenase (NADP+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
|
|
|
BRENDA:
BS230636;
BS257227
MetaCyc:
RXN-17412
SABIO-RK:
9886
|
|
|
|
cholic_acid <=> 3alpha,12alpha-dihydroxy-5beta-chol-6-enoate + H2O
|
not assigned
|
–
|
|
|
KEGG:
R02798
|
|
|
|
deoxycholate + FAD + H2O <=> cholic_acid + FADH2
|
not assigned
|
–
|
|
|
KEGG:
R07220
|
|
|
|
UDP-galactose + cholic_acid <=> beta-D-galactosyl-cholate + UDP
|
2.4.1.M19
|
–
|
|
|
MetaCyc:
RXN-18317
|
|
|
|
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + cholic_acid <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate + choloyl-CoA
|
2.8.3.25
bile acid CoA-transferase
|
–
|
M
|
|
MetaCyc:
RXN-21335
|
|
|
|
7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + cholic_acid <=> 7alpha-hydroxy-3-oxochol-4-enoate + choloyl-CoA
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-21338
|
|
|
|
7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + cholic_acid <=> choloyl-CoA + 7beta-hydroxy-3-oxochol-4-enate
|
2.8.3.25
bile acid CoA-transferase
|
–
|
M
|
|
MetaCyc:
RXN-21344
|
|
|
|
cholic_acid <=> cholic_acid
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN0-527
|
|
|
|
dATP + cholic_acid + CoA <=> dAMP + diphosphate + choloyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
|
|
BRENDA:
BS344
|
|
|
|
UDP-glucuronate + cholic_acid <=> UDP + cholic_acid_24-beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS436013
|
|
|
|
cholic_acid + NADH <=> 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic_acid + NAD+
|
1.1.1.159
7alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS384447
|
|
|
|
cholic_acid + NAD+ <=> 12-ketochenodeoxycholic_acid + NADH
|
1.1.1.176
12alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS230313-a
|
|
|
|
cholic_acid + NAD+ <=> (5beta,7alpha,8xi,12alpha)-7,12-dihydroxy-3-oxocholan-24-oic_acid + NADH + H+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS423119-a
|
|
|
|
Dehydrocholic_acid + NADH <=> cholic_acid + NAD+
|
1.1.1.112
indanol dehydrogenase
|
–
|
|
|
BRENDA:
BS187026-a
|
|
|
|
12-ketochenodeoxycholic_acid + NADP+ <=> cholic_acid + NADPH + H+
|
1.1.1.176
12alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS230322
|
|
|
|
cholic_acid + NADP+ <=> 12-ketochenodeoxycholic_acid + NADH + H+
|
1.1.1.176
12alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS439332
|
|
|
|
cholic_acid + NADP+ <=> 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic_acid + NADH
|
1.1.1.159
7alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS187364
|
|
|
|
cholic_acid + NADP+ <=> (5beta,7alpha,8xi,12alpha)-7,12-dihydroxy-3-oxocholan-24-oic_acid + NADPH + H+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS423119
|
|
|
|
Dehydrocholic_acid + NADPH <=> cholic_acid + NADP+
|
1.1.1.112
indanol dehydrogenase
|
–
|
|
|
BRENDA:
BS187026
|
|
|
|
allodeoxycholoyl-CoA + cholic_acid <=> allodeoxycholate + choloyl-CoA
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
|
BRENDA:
BS437005
|
|
|
|
cholate-7-amido-4-methylcoumarin-3-acetic_acid + H2O <=> cholic_acid + 7-amino-4-methylcoumarin-3-acetic_acid
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS449762
|
|
|
|
cholic_acid + thio-NAD+ <=> 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic_acid + thio-NADH
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
|
BRENDA:
BS372704
|
|
|
|
3''-phosphoadenylyl-sulfate + cholic_acid <=> adenosine_3'',5''-bisphosphate + cholic_acid_sulfate
|
2.8.2.14
bile-salt sulfotransferase
|
–
|
|
|
BRENDA:
BS360193
|
|
|
|
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oylglycine + H2O <=> cholic_acid + glycine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS140406
|
|
|
|
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyltaurine + H2O <=> cholic_acid + taurine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS140407
|
|
|
|
cholyl-alpha-aminomethanesulfonic_acid + H2O <=> cholic_acid + aminomethanesulfonic_acid
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS140416
|
|
|
|
cholyl-beta-Ala + H2O <=> cholic_acid + beta-Alanine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS140414
|
|
|
|
cholyl-beta-Ala + H2O <=> cholic_acid + DL-alanine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS140415
|
|
|
|
cholylsarcosine + H2O <=> cholic_acid + sarcosine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
|
BRENDA:
BS140418
|
|
|
|
cholic_acid + UDP-glucuronate <=> cholic_acid_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS322206
|
|
|
|
ATP + H2O + cholic_acid <=> ADP + phosphate + cholic_acid
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS402458
|
|